Download Drug Design and Discovery in Alzheimer's Disease by Atta-ur-Rahman, Muhammad Iqbal Choudhary PDF

By Atta-ur-Rahman, Muhammad Iqbal Choudhary

Drug layout and Discovery in Alzheimer’s Disease contains specialist studies of modern advancements in Alzheimer's illness (AD) and neurodegenerative sickness study. initially released by means of Bentham as Frontiers in Drug layout and Discovery, quantity 6and now disbursed by means of Elsevier, this compilation of the 16 articles, written by means of prime worldwide researchers, specializes in key advancements within the figuring out of the illness at molecular degrees, id and validation of molecular objectives, in addition to cutting edge techniques in the direction of drug discovery, improvement, and supply. starting with an outline of advert pharmacotherapy and latest blockbuster medicinal drugs, the studies conceal the opportunity of either traditional and artificial small molecules; the position of cholinesterases within the on-set and development of advert and their inhibition; the function of beta-site APP clearing enzyme-1 (BACE-1) within the construction of β-amyloid proteins, one of many key purposes of the development of advert; and different goals pointed out for advert drug discovery.

  • Edited and written by way of top specialists in Alzheimer’s ailment (AD) and different neurodegenerative ailment drug development
  • Describes current medicines for advert and present molecular realizing of the condition
  • Reviews fresh advances within the box, together with assurance of cholinesterases, BACE-1, and different drug improvement targets

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Extra resources for Drug Design and Discovery in Alzheimer's Disease

Example text

Stricker, B. H. Nonsteroidal anti-inflammatory drugs and the risk of Alzheimer’s disease. N. Engl. J. , 2001, 345 (21), 1515-1521. Cummings, J. ; Cole, G. Alzheimer disease. J. Am. Med. , 2002, 287 (18), 23352338. ; Fratiglioni, L. Combined effects of APOE genotype, blood pressure, and antihypertensive drug use on incident AD. Neuorology, 2003, 61 (5), 655-660. Craig, L. ; Hong, N. ; McDonald, R. J. Revisiting the cholinergic hypothesis in the development of Alzheimer's disease. Neurosci. Biobehav.

Loy, J. ; Verdoorn, T. ; Smith, D. ; Felsenstein, K. M. Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}secretase inhibitor. J. Pharmacol. Exp. , 2005, 312 (2), 635-643. [111] Imbimbo, B. P. Alzheimer’s disease: gamma secretase inhibitors. Drug Discov. Today: Therapeutic Strategies. 2008, 5 (3), 169-175. ; García, I. Review of theoretical studies for prediction of neurodegenerative inhibitors.

Lim, J. ; Tanzi, R. ; Masters, C. ; Bush, A. I. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer’s disease transgenic mice. Neuron, 2001, 30 (3), 665-676. Ritchie, C. ; Bush, A. ; Li, Q. ; Tanzi, R. ; Masters, C. L. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and Pharmacotherapy of Alzheimer's Disease [145] [146] [147] [148] [149] [150] [151] [152] [153] [154] [155] [156] Drug Design and Discovery in Alzheimer’s Disease 37 toxicity in Alzheimer disease: a pilot phase 2 clinical trial.

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