By Jean-Adolphe Rondal PhD, Juan Perera
Individuals with Down Syndrome convey a selected developmental profile with strengths in social figuring out and visible studying and reminiscence, and extra problems with motor tactics, speech and language, and auditory-vocal momentary reminiscence. it is necessary that oldsters, practitioners and academics comprehend this and adapt interventions and academic ways to take account of this actual profile.
This is the single ebook thus far that explains the developmental profile of individuals with Down Syndrome from its many various angles. It covers quite a number views, together with the biology, psychology, speech and language, overall healthiness care, and social competence of either childrens and adults with Down Syndrome. the entire details is collected and put within the context of the neuro-genetic technology that's constructing round this sector.
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Additional resources for Down Syndrome: Neurobehavioural Specificity
Nat Rev Genet, 5, 725–738. , Caldwell, M. , et al. (2002) Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from foetuses with Down’s syndrome: a gene expression study. Lancet, 359, 310–315. DOWN SYNDROME: FROM PATHOLOGY TO PATHOGENESIS 29 Baxter, L. , Moran, T. , Richtsmeier, J. , Reeves, R. H. (2000) Discovery and genetic localization of Down syndrome cerebellar phenotype using the Ts65Dn mouse. Hum Mol Genet, 9, 195–202. Becker, L. , Armstrong, D. , Chan, F.
The metabolism of Abeta itself can produce oxidative stress (Nelson & Alkon 2005). Moreover, Abeta has been found to cause aberrant mitochondrial metabolism through binding to a mitochondrial alcohol dehydrogenase (ABAD) that inhibits its activity (Lustbader et al. 2004; Takuma et al. 2005). This interaction has been hypothesised to directly contribute to oxidative stress in AD. Moreover, oxidation of Abeta itself has been hypothesised to be an early event in amyloid plaque biogenesis and perhaps in Abeta pathogenesis (Head et al.
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