By Bruno Vincenzi MD, PhD, Anna Maria Frezza MD (auth.), Antonio Russo, Stefano Iacobelli, Juan Iovanna (eds.)
Gene expression experiences have published diagnostic profiles and upregulation of particular pathways in lots of sturdy tumors. The explosion of recent info in gene expression profiling may almost certainly bring about the advance of adapted remedies in lots of stable tumors. moreover many reports are ongoing to validate those signatures additionally in predicting reaction to hormonal, chemotherapeutic and specified brokers in breast melanoma in addition to in different tumors.
Diagnostic, Prognostic and healing worth of Gene Signatures offers readers an invaluable and accomplished source concerning the variety of functions of microarray expertise in oncological ailments. issues coated comprise gene signatures and tender tissue sarcomas, prognostic relevance of breast melanoma signatures, gene expression profiling of colorectal melanoma and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic melanoma, and gene signatures in head/neck, lung and gastric tumors.
Diagnostic, Prognostic and healing worth of Gene Signatures might be of significant price to citizens and fellows, physicians, pathologists and clinical oncologists.
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Extra resources for Diagnostic, Prognostic and Therapeutic Value of Gene Signatures
In a recent study, Koh et al. have analyzed 12 matched primary and metastatic colorectal carcinomas, and have identified 80 genes differentially expressed by means of a supervised hierarchical clustering . The metastasis was distinguished from the corresponding primary tumor in half of the metastases analyzed using a specific set of genes identified. Among 80 genes, MMP1, MMP-2, MMP3, MMP-13, COL1A2, and CXCL3 were up-regulated in primary colon carcinoma, and SOX15, LIMS1, SERPINA3, CYP1B1, NAT5, SPP1, and SERPINA1 were up-regulated in metastatic colon carcinoma.
54. Russnes HG, Vollan HK, Lingjaerde OC, et al. Genomic architecture characterizes tumor progression paths and fate in breast cancer patients. Sci Transl Med. 2010;2:38–47. Chapter 3 Gene Signatures in CRC and Liver Metastasis Daniele Fanale, Lidia Corsini, Sergio Rizzo, and Antonio Russo Introduction Colorectal cancer (CRC) is one of the most common causes of cancer-related death with a worldwide incidence of almost a million cases annually in both males and females . The accelerated decrease in CRC incidence rates from 1998 to 2006 largely reflects the advances in diagnosis and treatment that have enabled to detect and remove precancerous polyps .
SERPINA1 and SERPINA3 were associated with a poor prognosis in colon cancer and are overexpressed in metastatic breast carcinoma. Furthermore, the up-regulated genes in metastatic colon cancer include genes involved in embryonic development (GA17), cell adhesion (ADRM1), RNA binding (SNRPB2), transcriptional activity (TWIST1 and ETV4), cell cycle and proliferation (CKS2), DNA repair (RPA3), signal transduction (PRDX4), and prefolin complex (VBP1). Down-regulated genes in metastatic colon cancer included genes involved in the cell–cell adhesion (ICAM4), extracellular region (GUCA2A) and carbonate dehydratase activity (CA4).